Free carboxylate salt SPG membrane emulsification device regulatory solution

Pubdate：2016-07-01　Click：5248

Free carboxylate salt SPG membrane emulsification device regulatory solution alginate microspheres and its doxorubicin loading and release behavior research

Using membrane emulsification - gelation prepared calcium alginate microspheres narrow particle size distribution with different concentrations of sodium chloride solution treated microspheres microspheres to regulate the content of free carboxylate by atomic absorption spectroscopy and infrared. Spectroscopic Characterization of changes in microspheres of calcium, sodium and chemical group, proof salt treatment after the ion substitution of sodium calcium alginate process occurs within the microspheres, alginic acid in acid chelated into the root causes of freedom state. microspheres treated with salt adsorption of small molecule anti-cancer drug doxorubicin positively charged capacity greatly increased, which microspheres after drug loading concentration of 1.8% sodium chloride solution process reached 1310μg / mg, 10 times the untreated microspheres. drug-loaded microspheres having a pH-sensitive release behavior in PBS pH5.5 solution in the release rate and release

Last one Next Return