PCATALOG
Formulation development and in-vitro evaluation of fast dispersible, taste masked Aceclofenac compacted pellets
Pubdate：2020-07-29 Click：777
The objective of this study was to develop Aceclofenac fast dispersible compacted pellets with improved taste and fast drug release. Pellets were prepared by extrusion-spheronization technique followed by direct compression to make compacted pellets. Formulations were comprised of sucrose, mannitol, ac-di-sol, aspartame, pine apple flavor and magnesium stearate. A mixture of distilled water and isopropyl alcohol (1:1) was used for wet massing. The effect of acdi-sol on the drug release pattern was examined and dissolution profile comparison was established. All formulations followed First order and Weibull models and f values indicated dissimilarity with the marketed immediate release product. Taste of compacted pellets was evaluated by a panel of 12 human volunteers. Formulation P5 was found to be an optimized formulation due to satisfactory quality attributesrds.
