PCATALOG
Pelletization techniques uesed in pharmaceutical fields
Pubdate：2021-10-28 Click：840
Pelletization is a technique that enables the formation of spherical beads or pellets with a mean diameter usually ranging from 0.5 to 2.0 mm. These pellets can evantually be coated and very ofen used in controlled-release dosage forms. The use of pelletization and pellets leads to an improvement in the flowability, appearance and mixing properes, thus avoiding excessive dust and reducing segregation and, generally, eliminating undesirable properties and improving the physical or chemical properties of fine powders. Pellets are prepared by different techniques, such as extrusion and spheronisation, rotogranulation, solution, suspension or powder layering, spray-drying or spray-congealing. The aim of this paper is to review some general aspects about pellets and pelletization and some common techniques used in the pharmaceutical industry. Several alternative methods are currently being developed, such as: hot-melt extrusion, freeze pelletization, emulsion / solvent evaporation, granulation using foamed aqueous binders, etc.
In the later decades, pelletization has gained an increased interest, especially due to the posibilities to use pellets in the development of modified-re-lease solid oral dosage forms.Currently there are several pelletization meth-ods, the most widely used being etxrusion / spher-onization.Due to the good technological, pharmacokinetic and biopharmaceutic characteristics of the pellets and the flexibility of the maufacturing processes in-volved, pellets are expected to continue to play a major role in design and fabrication of solid dosage forms.