HPCCC

Model Type / Volumes Hydrodynamic Counter-Current Chromatography (CCC / HSCCC / HPCCC / HPL-LC™)

Novel & New: Coils can be custom made in PTFE, PFA, PEEK, Stainless Steel (S/S) or Titanium. “G” Force can be Standard (S)(80 to 150G), High (H)(250G+) or unique to us, our new Ultra (U) (350G+), (UPCCC™) / (UPL-LC™). 

Your Instrument could have coils with, 1, 2, 3 or even 4 different id bores, pressure ability of 1000+ psi, typical “on-column” loadings of 5 to 40 g per 1 litre. You can have both customised volumes & bores. 

Unique to us, bores available from 1 mm to 30+ mm id, with flows up to multiple litres/min

IntroPrep™ ~20 to 140 ml. coil id/volume

L-LcMSPrep™ ~20ml to 1mm id bore and ~110 ml/2.1mm id bore, both S/S coils 

QuikPrep™ up to ~750 ml, price depending number coils, coil 1d / volume 

LabPrep™ up to ~2000ml, price depending number coils, coil 1d / volume

ProcessPrep™ any volume, mutually agreed bore or coil material, 3 to 100’s litres. 

ILPrep™ any volume, high pressure Ionic Liquids unit for chromatograhy and extraction. 

DualFlow™ any volume for chromatograhy and extraction. Existing usrs can upgrade.

    High backpressure, Stainless Steel coiled 18-litre Quattro ProcessPrep™ HPL-LC™ unit start from LESS THAN HALF PRICE of low backpressure PFA coiled (only ~105psi), 18 litre UK competitors’ process HPCCC units? Being modular the process Quattro HPL-LC™ (starting from 3 litres), allow you to start your process chromatography or extraction with at low-cost with one unit. Add capacity only as required. Perfect for Simulated Moving Bed use. Like to have different bobbins sets with different bores / volumes for different requirements or SMB? You can with Quattro Process HPL-LC™, but not with competitors. 

    New Quattro HPL-LC™ Mk 8 typical sample preparation times are only 20 to 60+ minutes. Solvent usage for same mass injected can be up to 90% less than Flash or HPLC, and also 40 to 90% often less than many CCC / HSCCC / HPCCC / CPC / HPCPC, from HSCCC / HPCCC competitors.

 

Model Type / Volumes Hydrostatic CCC, Droplet Centrifugal Partition Chromatography (CPC / HPCPC )

Novel & New: Sun rotors can be custom made in Stainless Steel or Titanium (for proteins etc). 

Instruments can have, 1 or 2 different id cell (chamber) bores, with pressure abilities of 1000+ psi, with typically “on-column” loadings of 5 to 40 g per 1 litre. HPCPC is ideal for MAB’s, proteins, peptides & enzymes, other organic and inorganic extractions or chromatography purifications.

Unique to us, custom design options for Quattro HPCPC™. You choose cell / chamber bores, available 6 mm to 22+ mm id, chose different chamber id’s, numbers, and volumes on same instrument by mutual agreement. Nobody else offers you the same custom design flexibility. 

IntroPrep HPCPC™ Laboratory Instruments. ~100 ml to 1,000ml, Stainless Steel or Titanium rotor, 6 mm bore cell / chambers, other id’s by mutual agreement 

QuikPrep HPCPC™ Laboratory or Pilot Plant Instruments. ~100 ml to 4,500ml, Stainless Steel or Titanium rotor. Options of 6 mm or 10 mm bore cell / chambers, other id’s by mutual agreement 

ProcessPrep HPCPC™ Process ATEX Design. Stainless Steel or Titanium rotor, with 6,000 to 18,000+ ml modules. Any number 6 litre modules can be used in series or for Simulated Moving Bed (SMB).

Partitron HPCPC™ Process ATEX Design. Titanium rotor only, with 25,000+ ml modules. Parallel use multi-25 litre rotor units allows up-to any volume, even to 100’s litres. 22 mm bore chambers.

Partitron HPCPC & Quattro HPCPC both suitable, standard solvents, Ionic Liquid or Liquid CO2 for Pilot or Process Plant SFE, SFC, Liquid-Liquid Extraction and Chromatography. 

    Partitron & Quattro HPCPC™ ATEX approved, Intrinsically Safe units are worldwide the only HPCPC (High Performance Centrifugal Partition Chromatography) with TITANIUM ROTOR OPTIONS and STOPPED USE OF ANY LEAK-PRONE PTFE SEALS, so suitable steam cleaning. Many of our competitors only have units where their parent academic University / Research Institute shareholders obtained grants for “one-off” builds. We have supplied industrial process units for several years.

The modular Process Compatible, ATEX specification, Quattro HPCPC start at 6 litre modules & ATEX Partitron HPCPC™ range begins at 25 litre units. Scale-up “in-parallel” by use of multiple 6 or 25 litre units easily available. Add capacity with additional modular 6 or 25 litre rotors as & when required. 

Or consider our Process HPCPC for Simulated Moving Bed use, standard solvent or IONIC LIQUID solvents or Liquid CO2 use for CHROMATOGRAPHY OR EFFICIENT EXTRACTION.

    Countercurrent (Hydrodynamic CCC) Chromatography

  All Quattro Hydrodynamic CCC models share the same planet & sun radii, beta values, speed / “G” Force options. We will now guarantee in writing the scale-up for any given bore, by increase in coil length / volume. In the vast majority of cases predictable scale-up occurs for different bore id’s as well. But rare exceptions occur even when you maintain all key design parameters. Our almost 20 years of experience suggests the more key design parameters you change, more scale-up failures occur, irrespective of constant “G” force. We challenge anyone to dispute this statement. Occasional scale-up failures that we experience are no different to occasional scale-up exceptions that occur in Process HPLC / Flash Chromatography for certain target / matrix / phase combinations

  But uniquely to us, we recognise this and give you lower-cost laboratory scale Quattro LabPrepPlus™ units that can be used for full process scale testing at bores up to 30+ mm. No competitor gives you lab-scale units to test process-scale bore id’s etc. Do you believe competitors’ suggestions based on very limited Arizona / HEMWat / GUESS mixture solvent / target choices, that their instrument designs, with mini-units ranging from cotton reel sized bobbins rotating at ~2000 rpm, will behave chromatographically the same as maxi-units which you could stand inside rotating at ~800 rpm, simply because “G” Force is the same at 240G, for all target / matrix / biphasic solvent systems? No? Nor do we. We also believe HEMWat has limited applications, excepting restricted polarity pharmaceuticals, they misleading show. They say 90+% their preparations use HEMWat. We say HEMWat useless for most proteins, many peptides, many enzymes, very many natural products / synthetic mixtures. Your views?

Our genuine, experimentation proven knowledge is based on our almost 20 years of CCC / HSCCC / HPCCC / CPC / HPCPC / HPL-LC experience. Please ask competitors, to back their potentially misleading claims by guaranteeing to you their scale-up for all targets / matrices / biphasic systems in writing. What happens when you buy a competitors’ £400000+ / 18+ litre / 10 mm id bore process unit and scale up fails? Would it be cost-effective to optimise a method on such an expensive unit.